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International Journal of Epidemiology 2001;30:1425-1427
© International Epidemiological Association 2001

Cancer

Commentary: Regional variations in oesophageal and gastric cardia cancers—implications and practice

JA Eksteena, A Latchforda, SJ Thomasb and JA Jankowskia

a Queen Elizabeth Hospital, University of Birmingham, UK. E-mail: Janusz.Jankowski@university-b.wmids.nhs.uk
b Department of Maxillofacial Surgery, University of Bristol, Bristol, UK.

The incidence of oesophageal adenocarcinoma (OA) has seen a rapid increase throughout the last 20 years in the western world and has now surpassed that of oesophageal squamous carcinomas in developed countries. The diagnosis is often at an advanced stage and is almost uniformly associated with a poor prognosis and mean survival of less than one year.1 Oesophageal adenocarcinoma is strongly associated with gastro-oesophageal reflux disease (GORD) and Barrett's Metaplasia (BM). It is now widely accepted that OA does not develop de novo but . . . [Full Text of this Article]

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