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International Journal of Epidemiology 2001;30:1040-1041
© International Epidemiological Association 2001

Methodology

Commentary: Gene-environment interactions: fundamental yet elusive

Paul Burton

Department of Epidemiology and Public Health, University of Leicester, 22–28 Princess Road West, Leicester LE1 6TP, UK. E-mail: pb51@le.ac.uk

The article authored by Luan et al.1 is most timely. A primary aim of a large National Cohort study currently being designed under the auspices of the United Kingdom Medical Research Council, the Wellcome Trust and the Department of Health is to investigate the role of gene-environment interactions in the aetiology of complex diseases. The study currently aims to recruit and track approximately 500 000 middle-aged subjects from across the UK. It represents a major investment in the future of British biomedical science, and it is critical that we properly understand the ‘science’ underpinning the detection and interpretation of gene-environment interactions. However, there . . . [Full Text of this Article]

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