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International Journal of Epidemiology 2001;30:862-863
© International Epidemiological Association 2001

Cardiovascular Disease

Commentary: Are birthweight and cardiovascular associations due to fetal programming?

Yoav Ben-Shlomo

Department of Social Medicine, Canynge Hall, Whiteladies Road, Bristol BS8 2PR, UK. E-mail: y.ben-shlomo@bristol.ac.uk

The first 10% of the full text of this article appears below.

The paper by Mogren and colleagues1 provides further evidence for an association between low birthweight (LBW) and various measures of cardiovascular risk. In addition, they suggest potential interactions between LBW and a positive family history of premature cardiovascular disease and maternal pre-eclampsia or hypertension during pregnancy in increasing offspring blood pressure. They conclude that ‘from a public health perspective, heredity was more important than low birthweight (LBW) for elevated systolic blood pressure’.

The observation that birthweight is inversely associated with blood pressure is one of the most consistent and convincing features of the ‘fetal origins hypothesis’.2 However, similar associations with . . . [Full Text of this Article]


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