International Journal of Epidemiology 2001;30:807-808
© International Epidemiological Association 2001
Maternal and Child Health |
Commentary: Does use of food supplements influence the twin rate? New evidence from a randomized controlled trial
Maternal Nutrition Group, Danish Epidemiology Science Centre, Statens Serum Institut, DK-2300 Copenhagen S, Denmark. E-mail: sfo@ssi.dk
Accepted 21 September 2000
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Few factors have been identified as causes of multiple births.1 Ovulation-inducing drugs are known to substantially increase the rate, but this is likely to explain only a minority of all occurrences. A number of other conditions have been found to be associated with multiple birth, including seasonality at birth, maternal age, social class, and diet.1 However, the evidence relies nearly exclusively on observational studies, since very few randomized interventions have been undertaken in the peri-conceptional period which are large enough to enable the study of a rare outcome such as multiple birth.
Until recently there was only evidence available from one
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