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International Journal of Epidemiology 2001;30:598-599
© International Epidemiological Association 2001

Other Original Papers

Commentary: Searching for risks for Alzheimer's disease

Carol Brayne

Institute of Public Health, University of Cambridge, Forvie Site, Robinson Way, Cambridge CB2 2SR, UK. E-mail: carol.brayne@medschl.cam.ac.uk

The search for risk factors for Alzheimer's disease is notoriously problematic, both for genetic and acquired risk. Why is it so difficult to look for risks? The study published by Tyas et al. exemplifies many of these difficulties, but also shows why we should persist.

The range of studies which have informed possible risks for dementia varies from studies of very rare families with autosomal dominant patterns of Alzheimer's disease through case-controlled studies and prospective observational cohort studies to randomized control trials of interventions (such as the WISDOM trial of hormone replacement therapy and dementia in the United Kingdom).1 The study presented in this edition is a prospective cohort study. Tyas et al. present data from a longitudinal study of people aged 65 and above, with collection from the non-demented at outset of putative risk factors . . . [Full Text of this Article]

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