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International Journal of Epidemiology 2001;30:15-23
© International Epidemiological Association 2001
Review |
The nutritional basis of the fetal origins of adult disease
Research Centre for Developmental Medicine and Biology, School of Medicine, Private Bag 92019, Auckland, New Zealand. E-mail: j.harding@auckland.ac.nz
Keywords Nutrition, fetal growth
It is now widely accepted that the risks of a number of chronic diseases in adulthood may have their origins before birth. Such diseases include non insulin-dependent diabetes mellitus, hypertension and coronary heart disease. Professor David Barker and colleagues in Southampton have produced a large proportion of the data in this field over the last decade,1 although the relationship between early life events and adult disease had been raised many years earlier.2 Most of this work has been based on epidemiological studies wherein cohorts of subjects whose birth records were available have been traced into adulthood. They have shown that measurements made on babies at birth, including birthweight, length, body proportions and placental weight, are strongly related to either later disease incidence (coronary heart disease mortality, non-insulin-dependent diabetes)3,4 or risk factors for those diseases (hypertension, glucose intolerance, hyperlipidaemia).1,5,6 Such relationships have been shown to hold in many different populations and
Why nutrition?
Distinguishing fetal from maternal nutrition
Distinguishing birthweight from fetal growth
Timing and balance of nutrients
Multigenerational effects
Summary
Acknowledgments
References
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