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International Journal of Epidemiology 2001;30:143-144
© International Epidemiological Association 2001

Cardiovascular Disease

Commentary: Beyond beta-carotene—antioxidants and cardiovascular disease

AR Ness

University of Bristol, Department of Social Medicine, Canynge Hall, Whiteladies Road, Bristol BS8 2PR, UK. E-mail: andy.ness@bris.ac.uk

In 1989 in an article entitled ‘Beyond cholesterol: modifications of low-density lipoprotein that increase its atherogenicity’ that appeared in the New England Journal of Medicine Daniel Steinberg et al. highlighted the potentially important role of oxidation of low-density lipoprotein (LDL)-cholesterol in atherogenesis.1 This laboratory work led epidemiologists to examine the association between intake of antioxidants (substances that might stop the oxidation of LDL-cholesterol such as beta-carotene) in the diet of free-living humans and subsequent cardiovascular disease.

Observational studies reported a significantly lower risk of cardiovascular death in those who ate diets rich in beta-carotene. In a meta-analysis the . . . [Full Text of this Article]

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