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International Journal of Epidemiology 2000;29:405-407
© International Epidemiological Association 2000

Blood type and family cancer history in relation to precancerous gastric lesions

Wei-Cheng Youa, Jun-Ling Mab, Wei-dong Liuc, Mitchell H Gaila, Yun-Sheng Changb, Lian Zhangb, Yuan-Reng Hud, Joseph F Fraumeni, Jra and Guang-Wei Xub

a National Cancer Institute, Bethesda, MD 20892, USA.
b Beijing Institute for Cancer Research and School of Oncology, Beijing Medical University, Beijing, China 100034.
c Linqu Public Health Bureau, Linqu, Shandong, China 262600.
d Westat, Inc., Rockville, MD 20850, USA.

Reprint requests to: Wei-Cheng You, Division of Cancer Epidemiology and Genetics, National Cancer Institute, EPS Room 8030, Bethesda, MD 20892, USA.

Background The increased odds of stomach cancer among subjects with blood type A have been reported in epidemiological studies.

Aim To study the relation of family history of gastric cancer and ABO blood type with precancerous gastric lesions in a high-risk area for stomach cancer.

Subjects and setting We examined 3400 adults aged 35–64 in a population-based gastric endoscopic screening in a county in China with one of the highest rates of stomach cancer in the world.

Methods In this cross-sectional study, data on family cancer history, ABO blood type and other characteristics of the participants were obtained by interview and blood test. Responses were compared between those with the most advanced gastric lesions, dysplasia (DYS) or intestinal metaplasia (IM), versus those with chronic atrophic gastritis (CAG) or superficial gastritis (SG).

Results The prevalence odds ratio (OR) for blood type A relative to other types was 1.39 (95% CI : 1.12–1.73) for DYS and 1.28 (95% CI : 1.06–1.53) for IM. The OR associated with parental history of stomach cancer was 1.88 (95% CI : 1.20–2.95) for DYS, but the numbers were too small to evaluate aggregation among siblings. The combined OR associated with blood type A and a parental of history of gastric cancer was 2.61 (95% CI : 1.59–4.30) for DYS and 1.46 (95% CI : 0.93–2.31) for IM.

Conclusions The findings suggest that genetic factors play a role in developing precancerous gastric lesions.

Keywords Precancerous gastric lesions, ABO blood type, family stomach cancer history

Accepted 6 October 1999


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