International Journal of Epidemiology, Vol 28, 888-893, Copyright © 1999 by International Epidemiological Association
N Nakanishi, K Tatara, K Nakamura and K Suzuki
BACKGROUND: Few longitudinal studies on the determinants of increase in
serum uric acid (SUA) have been completed. METHODS: In all, 1445
hyperuricaemia-free (<7.5 mg/dl SUA, no medication for and no past
history of hyperuricaemia) male office workers aged 30-54 years of T
Corporation in Osaka, Japan were re-examined for six successive years.
Subjects who were found to be hyperuricaemic or had started medication for
hyperuricaemia during repeat surveys were defined as incident cases.
RESULTS: Among the subjects (n = 1365) not receiving medication for
hypertension, diabetes mellitus or renal disease, multivariate analysis
using the Cox proportional hazards model indicated that the incidence of
hyperuricaemia had significant relationships with body mass index (adjusted
hazard ratio [HR] = 1.13 for a 2 kg/m2 increase; 95% CI: 1.02-1.26), mean
blood pressure (HR = 1.07 for a 5 mmHg increase; 95% CI: 1.00-1.13), log
triglyceride level (HR = 2.21 for a 10 mg/dl increase; 95% CI: 1.12-4.37),
alcohol intake (HR = 2.33 for drinking 46.0 g of ethanol per day or more
relative to non-drinking; 95% CI: 1.55-3.50) and smoking (HR = 0.65 for
current-smoking relative to non-smoking; 95% CI: 0.46-0.92). Age (HR = 0.89
for a 5-year increase; 95% CI: 0.78-1.00) and haemoglobin A1c (HbA1c) (HR =
0.89 for a 0.5% increase; 95% CI: 0.78-1.00) achieved marginal
significance. CONCLUSIONS: Obesity, high blood pressure, high triglyceride
level, and alcohol intake are contributory factors for the development of
hyperuricaemia among middle-aged Japanese men. High HbA1c level and smoking
may be negative factors for the incidence of hyperuricaemia.
ARTICLES
Risk factors for the incidence of hyperuricaemia: a 6-year longitudinal study of middle-aged Japanese men
Department of Social and Environmental Medicine, Course of Social Medicine, Osaka University Graduate School of Medicine, Suita-shi, Japan.
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