International Journal of Epidemiology, Vol 28, 829-835, Copyright © 1999 by International Epidemiological Association
I Stucker, I de Waziers, S Cenee, J Bignon, A Depierre, B Milleron, P Beaune and D Hemon
BACKGROUND: We conducted a case-control study to examine the risk of lung
cancer in relation to GSTM1 polymorphism and cigarette smoking (primarily
of black tobacco) in a French population. METHODS: The 611 subjects were
301 incident lung cancer cases and 310 hospital controls. We were able to
constitute a DNA bank for 547 subjects (89.5%) and gather detailed
information on smoking history for all of them. Results presented here
concern 247 cases and 254 controls. RESULTS: Taking non- or light smokers
as the reference category, we estimated odds ratios (OR) of 4.2 (95% CI:
2.6-6.7) and 5.2 (95% CI: 3.3-8.3) for the medium and heavy smokers
respectively. On the other hand we estimated that the crude OR associating
GSTM1 with lung cancer was 1.3 (95% CI: 0.9-1.8). Furthermore our data do
not depart significantly from a multiplicative model of the combined
effects of smoking and GSTM1 deficiency. CONCLUSIONS: We conclude that
smoking and the GSTM1 gene are each a risk factor for lung cancer, and that
their combined effect does not differ significantly from that of a
multiplicative model.
ARTICLES
GSTM1, smoking and lung cancer: a case-control study
Epedemiologic and Statistical Research on Environment and Health, INSERM U 170, Villejuif, France.
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