International Journal of Epidemiology, Vol 26, S82-S90, Copyright © 1997 by International Epidemiological Association
H Boeing, S Bohlscheid-Thomas, S Voss, S Schneeweiss and J Wahrendorf
BACKGROUND: For the European Prospective Investigation into Cancer and
Nutrition (EPIC) study Germany, a self-administered food frequency
questionnaire (FFQ) was developed and tested for its relative validity and
reproducibility in 1991/1992. Study participants were 92 potential cohort
members. This paper reports results regarding retinol, carotenoids,
tocopherols and ascorbic acid. METHODS: Study participants were invited to
the study centre in Heidelberg once a month over one year. At each visit, a
24 hour recall was obtained. The FFQ was filled in twice with a 6-month
interval (FFQ1, FFQ2). In addition, a questionnaire on general consumption
frequencies of 14 broad food groups was completed. This information was
combined with estimates derived from FFQ2 and frequency-corrected food and
nutrient intakes were calculated (FFQcorr). Blood specimens were taken in
winter and summer 1992. RESULTS: The intraclass correlation of the FFQ
ranged from 0.65 to 0.67 for retinol, tocopherols, carotenoids, and
ascorbic acid. Intake of carotenoids by FFQcorr showed de-attenuated
Pearson correlation coefficients with blood values in the order of 0.37,
and with recall data of 0.44. Respective correlations for retinol were 0.21
and 0.29, for tocopherols 0.18 and 0.52, and for ascorbic acid 0.36 and
0.69. Errors of FFQcorr and 24-hour diet recalls were not correlated.
CONCLUSIONS: In general, it was demonstrated that the FFQ was able to rank
participants into biologically meaningful categories of intake or blood
concentrations for carotenoids and ascorbic acid, but misclassification was
higher for tocopherol and retinol.
ARTICLES
The relative validity of vitamin intakes derived from a food frequency questionnaire compared to 24-hour recalls and biological measurements: results from the EPIC pilot study in Germany. European Prospective Investigation into Cancer and Nutrition
Unit of Medical Epidemiology, Deutsches Institut fur Ernahrungsforschung Potsdam-Rehbrucke, Bergholz-Rehbrucke, Germany.
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