International Journal of Epidemiology, Vol 26, 757-764, Copyright © 1997 by International Epidemiological Association
DS Freedman, L Gates, WD Flanders, OW Van Assendelft, JJ Barboriak, MR Joesoef and T Byers
BACKGROUND: Although counts of leukocytes differ substantially between
blacks and whites, and are predictive of ischaemic heart disease (IHD),
racial differences in counts of leukocyte subpopulations have received less
attention. METHODS: We examined black/white differences in leukocyte
subpopulations among 3467 white and 493 black 31-45 year-old- men who had
previously served in the US Army. Laboratory determinations were performed
at a central location during 1985-1986. RESULTS: Black men had an 840
cell/microliter (or 15%) lower mean total leukocyte count than did white
men, largely due to a 960 cell/microliter (or 25%) lower mean neutrophil
count. Although black men also had a 20% lower mean monocyte count (= 70
cells/microliter) than did white men, their mean lymphocyte count was 10%
higher (approximately = 200 cells/microliter). Counts of various leukocyte
subpopulations were associated with cigarette smoking, haemoglobin levels,
platelet counts, and several other characteristics, but black/white
differences in counts of neutrophils, lymphocytes, monocytes and other
subpopulations could not be attributed to any of the examined covariates.
CONCLUSIONS: Despite the relatively low counts of leukocytes and
neutrophils among black men, their lymphocyte counts are generally higher
than those among white men. It is possible that black/white differences in
counts of various cell types may influence race-specific rates of IHD, and
future studies should attempt to assess the importance of leukocyte
subpopulations in the development of clinical disease.
ARTICLES
Black/white differences in leukocyte subpopulations in men
National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control, Atlanta, GA 30341-3724, USA.
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