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© 1994 Oxford University Press

other

Demographic Factors Associated with HTLV-1 Infection in a Gabonese Community

JEAN YVES LE HESRAN*, ERIC DELAPORTE*,**, CLAUDE GAUDEBOUT*, ARNAUD TREBUCK{ddagger}, DIRCK SCHRIJVERS**, RICHARD JOSSE{dagger}, MARTINE PEETERS*, HENRI CHERINGOU{ddagger}, ALAIN DUPONT** and BERNARD LAROUZE*,

* INSERM U13 et Fondation Léon M'ba, Hôpital Claude Bernard Paris, France
** CIRMF, Franceville, Gabon
{dagger} OCEAC, Yaoundé, Cameroun
{ddagger} Service des Grandes Endérnies, Franceville, Gabon

Reprint requests to: B Larouzé, INSERM U13/1MEA, 190 boulevard Mac Donald, 75019, Paris, France

An epidemiological study of human T-lymphotropic virus type 1 (HTLV-1) and syphilis has been carried out in a multiethnic community of seven neighbouring villages located in eastern Gabon on 1240 subjects over 5 years old (82.7% of the population in this age range). Antibodies to HTLV-1 (anti-HTLV-1) were detected by ELISA with confirmation by Westem Blot and antibodies to syphilis by Venereal Diseases Research Laboratory assay with confirmation by the ‘Treponema pallidum’ haemaglutination assay. The prevalence rate of anti-HTLV-1 was 8.5% and increased from 3.7% in the 5–14 years age group to 23.8% in the over 60 years age group. Logistic regression showed that the positivity for anti-HTLV-1 was associated with age, ethnic group and sex (higher prevalence in females). The seroprevalence rate of syphilis was 8.2%. Seropositivity for syphilis and HTLV-1 were related but age was a confounding variable in this relationship. This study showing a highly heterogenous distribution of HTLV-1 in a geographically limited area suggests the role of environmental and behavioural factors in HTLV-1 transmission.

Received 1 February 1994


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