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© 1994 Oxford University Press

research-article

The Distribution of Fasting Plasma Lipid Concentrations in the Offspring of Men with Premature Coronary Heart Disease in Europe. The EARS Study

The EARS Group*

*Reprint requests: Dr Denis St J O'Reilly, Department of Pathological Biochemistry, Royal Infirmary, Glasgow G4 0SF, Scotland, UK

Fasting plasma total holesterol, high density lipoprotein (HDL)-cholesterol, low density lipoprotein (LDL)-cholesterol and total triglyceride was measured In 682 unIversity students with a positive paternal history of coronary heart disease before the age of 55 years and 1312 age- and sex-matched controls recruited from 14 European centres. In male subjects, significant regional differences were observed for triglyceride (P< 0.005) and HDL-cholesterol (P< 0.05) but not for total or LDL-cholesterol. In female subjects, significant regional differences were observed for triglyceride (P< 0.05) and cholesterol (P < 0.05) but not for HDL- or LDL-cholesterol. Significant differences were observed between male cases and controls for cholesterol (P < 0.005) LDL-cholesterol (P < 0.005) and triglycerides (P < 0.005) but not for HDL-cholesterol. In females a significant difference was observed between cases and controls for LDL-cholesterol (P < 0.05) but not for total cholesterol, HDL-cholesterol or triglyceride.

Received 1 November 1993


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