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© 1993 Oxford University Press

other

Time Trends in Mortality for Multiple Myeloma in Spain, 1957–1986

MARINA POLLÁN*, GONZALO LÓPEZ-ABENTE* and ROSA PLÁ-MESTRE{dagger}

*Servicio de Epidemiologia del Cáncer, Nacional de Epidemiología Sinesio Delgado 6, 28029 Madrid, Spain
{dagger}Consejeria de Salud de la Comunidad Autónoma de Madrid

We studied age-and sex-specific mortality from multiple myeloma in Spain during the period 1957–1986. The presence of birth cohort and period effects was determined using a multivariate Poisson model. From an international perspective, multiple myeloma mortality in Spain during the 1980s was in the medium range. Adjusted rates for males and females were 1.36 and 0.96 per 100000 person-years, respectively. Multiple myeloma mortality rose exponentially during the study period, the annual increase was 11.0% in males and 10.5% in females, surpassing the increase observed in other countries. The analytical model ascribed most of this increase to a birth cohort effect. The interpretation of this phenomenon is difficult. Progressive improvements in detection and reporting, and an actual rising incidence may underlie the cohort effect.

Received 1 June 1992


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