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© 1992 Oxford University Press

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The Effects of Breastfeeding and Presence of Antibody to p40tax Protein of Human T Cell Lymphotropic Virus Type-I on Mother to Child Transmission

MIKI HIRATA, JUN HAYASHI, AKINORI NOGUCHI, KOYA NAKASHIMA, WATARU KAJIYAMA, SEIZABURO KASHIWAGI and TAKASHI SAWADA

Department of General Medicine, Kyushu University Hospital, Fukuoka and Tsukuba Research Laboratories, Eisai Company, Ibaraki, Japan

Hirata M (Department of General Medicine, Kyushu University Hospital, Fukuoka 812, Japan), Hayashi J, Noguchi A, Nakashima K, Kajiyama W, Kashiwagi S and Sawada 1. The effects of breastfeeding and presence of antibody to p40tax protein of the human T cell lymphotropic virus type-I on mother to child transmission. International Journal of Epidemiology 1992; 21: 989–994.

We examined the effects of various factors, including duration of breastfeeding, the status of mother's anti-p40tax, and titre of mother's anti-human T cell lymphototropic virus type-I (HTLV-I) on mother to child transmission of HTLV-I in 76 HTLV-I carrier mothers and 175 of their children. The overall prevalence of anti-HTLV-I among children was 16.0%. The prevalence of anti-HTLV-I among children breastfed for over 3 months was significantly higher (27.6%) than that of those breastfed for under 3 months (5.1%; P = 0.012). Of the 78 bottle-fed children, 10 (12.8%) were positive for anti-HTLV-I. In the children breastfed for over 3 months, the prevalence of anti-HTLV-I among 37 children of anti p40tax positive mothers was 37.8% and that of 21 children of anti-p40tax negative mothers was 9.5%, a significant difference (P = 0.044). These data suggest that about 13% of bottle-fed children born to carrier mothers are infected with HTLV-I by routes other than breast milk, and that the mother's anti-p40tax can serve as a marker of infectivity of HTLV-I in the case of breastfeeding for over 3 months.

Received 1 April 1992


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