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© 1992 Oxford University Press

research-article

Antibody to Hepatitis C Virus in Selected Groups of a Canadian Urban Population

CHANDAR M ANAND, KEVIN FONSECA, ROBERTA P WALLE, SANDRA POWELL and MIRIAM WILLIAMS

Provincial Laboratory of Public Health for Southern Albala 3030 Hospital Drive NW, PO Box 2490, Calgary, Alberta, Canada T2P 2M7

Anand C M (Provincial Laboratory of Public Health for Southern Alberta, 3030 Hospital Drive NW, P0 Box 2490, Calgary, Alberta, Canada T2P 2M7), Fonseca K, Walle R P, Powell S and Williams M. Antibody to hepatitis C virus in selected groups of a Canadian urban population. International Journal of Epidemiology 1992; 21: 142–145.

In an anonymous survey, 433 sara from Canadian individuals of selected categories were tested for the presence of antibody to hepatitis C virus (HCV) using a recombinant antigen-based immunoassay. About 50% of intravenous drug abusers (IVDA), 10% of transfusion recipients and an overall average of 7.9% of male homosexuals were reactive for antibody to HCV. Individuals with jaundice and negative hepatitis B virus (HBV) serology were not reactive for antibody to HCV compared with 26.7% of those with positive HBV serology. Similarly 58% of male Federal prisoners with positive HBV serology were also HCV-antibody reactive compared with 15% of those with negative HBV serology. A prevalence of 1.2% was recorded for individuals not in any of the above groups. Of 433 sara, 92 were reactive and the discrimination in absorbance values between reactive and not reactive samples was good except for 13 sera, eight of which gave values considerably higher than the average negative value and five which were just above the positive threshold.

Received 1 January 1991


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