Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (59)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by NEATON, J. D
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by NEATON, J. D
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 1990 Oxford University Press

research-article

The Relationship of White Blood Cell Count to Other Cardiovascular Risk Factors

For the Multiple Risk Factor Intervention Trial Research Group, LINDA K HANSEN*,{ddagger}, RICHARD H GRIMM, JR.**,§ and JAMES D NEATON{dagger}

*Department of Laboratory Medicine and Pathology Box 198 UMHC. University of Minnesota, Minneapolis, MN 55414, USA
**Division of Epidemiology 1-210 Moos Tower, 515 Delaware Street Southeast, University of Minnesota, Minneapolis, MN 55455, USA
{dagger}Coordinating Center for Biometric Research, 2221 University Avenue Southeast, Suite 200. University of Minnesota Minneapolis, MN 55414, USA

§: Reprints requests to: Dr R H Grimm

Baseline deta for the 12 866 men from the Multiple Risk Factor Intervention Trial was used to study factors related to white blood cell (WBC) count. White blood cell count was significantly higher in smokers (7853 cells/mm3) and exsmokers (7091 cells/mm3) who stopped smoking less than one year before than in ex-smokers who stopped more than one year before (6255 cells/mm3) and those who never smoked (6094 cells/mm3). In current cigarette smokers, white blood cell count was significantly related to number of cigarettes smoked, degree of inhalation, and duration of smoking (p<0.001 for each). In addition, white blood cell count was higher in non-cigarette smokers who smoked pipes, cigars, or cigarillos than among men who did not smoke tobacco (p<0.001). White blood cell count was lower in blacks (by 877 cells/mm3) and Orientals (by 634 cells/mm3) than in whites. Leukocyte count also showed a strong inverse association with high density lipoprotein (HDL)-cholesterol, a positive association with triglycerides independent of cigarette use, and a positive association with low density lipoprotein (LDL)-cholesterol in smokers only. Leukocyte counts were inversely related to total family income and alcohol consumption. We conclude that elevated leukocyte count is independently associated with other risk factors for coronary heart disease (CHD) such as amount and duration of smoking as well as an atherogenic profile, and these relationships should be considered when using white blood cell count as a predictor of coronary heart disease.

Received 1 June 1990


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Arch Intern MedHome page
M. Haim, V. Boyko, U. Goldbourt, A. Battler, and S. Behar
Predictive Value of Elevated White Blood Cell Count in Patients With Preexisting Coronary Heart Disease: The Bezafibrate Infarction Prevention Study
Arch Intern Med, February 23, 2004; 164(4): 433 - 439.
[Abstract] [Full Text] [PDF]

Home page
 Eur Heart JHome page
M. Frohlich, M. Sund, H. Lowel, A. Imhof, A. Hoffmeister, and W. Koenig
Independent association of various smoking characteristics with markers of systemic inflammation in men: Results from a representative sample of the general population (MONICA Augsburg Survey 1994/95)
Eur. Heart J., July 2, 2003; 24(14): 1365 - 1372.
[Abstract] [Full Text] [PDF]

Home page
 Toxicol Ind HealthHome page
E Akbas, F Soylemez, E Derici, G Borekci, and A Kanik
Effects of X-rays and cigarette smoking on leukocyte, lymphocyte and mitotic index values and SCE rates: the relationship between mitotic index and lymphocyte count
Toxicology and Industrial Health, March 1, 2003; 19(2-6): 81 - 91.
[Abstract] [PDF]

Home page
 J. Lipid Res.Home page
A. J. H. H. M. van Oostrom, T. P. Sijmonsma, C. Verseyden, E. H. J. M. Jansen, E. J. P. de Koning, T. J. Rabelink, and M. Castro Cabezas
Postprandial recruitment of neutrophils may contribute to endothelial dysfunction
J. Lipid Res., March 1, 2003; 44(3): 576 - 583.
[Abstract] [Full Text] [PDF]

Home page
 Am J EpidemiolHome page
C. D. Lee, A. R. Folsom, F. J. Nieto, L. E. Chambless, E. Shahar, and D. A. Wolfe
White Blood Cell Count and Incidence of Coronary Heart Disease and Ischemic Stroke and Mortality from Cardiovascular Disease in African-American and White Men and Women: Atherosclerosis Risk in Communities Study
Am. J. Epidemiol., October 15, 2001; 154(8): 758 - 764.
[Abstract] [Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
M. Frohlich, M. Sund, S. Russ, A. Hoffmeister, H. G. Fischer, V. Hombach, and W. Koenig
Seasonal Variations of Rheological and Hemostatic Parameters and Acute-Phase Reactants in Young, Healthy Subjects
Arterioscler. Thromb. Vasc. Biol., November 1, 1997; 17(11): 2692 - 2697.
[Abstract] [Full Text]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
C. M. Burchfiel, R. D. Abbott, D. S. Sharp, J. D. Curb, B. L. Rodriguez, and K. Yano
Distribution and Correlates of Lipids and Lipoproteins in Elderly Japanese-American Men: The Honolulu Heart Program
Arterioscler. Thromb. Vasc. Biol., November 1, 1996; 16(11): 1356 - 1364.
[Abstract] [Full Text]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.