© 1988 Oxford University Press
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Stability and Validity of a Single Serum Cholesterol Measurement in a Prospective Cohort Study
* Department of General Oncology, Radiumhemmet, Karolinska Hospital S-104 01 Stockholm, Sweden
Department of Community Medicine, Gävle Hospital S-801 17 Gävle, Sweden
Author of statistical appendix. Department of Cancer Epidemiology, Radiumhemmet, Karolinska Hospital S-104 01 Stockholm, Sweden
Tömberg S A (Department of General Oncology, Radiumhemmet, Karolinska Hospital, S-104 01 Stockholm, Sweden), Jakobsson K F S and Eldund G A. Stability and validity of a single serum cholesterol measurement in a prospective cohort study. International Journal of Epidemiology 1988, 17:797–803.
The variation of serum cholesterol level was studied in a cohort of 16 281 individuals, with repeated measurements of cholesterol. The mean correlation coefficient between the two cholesterol values taken with a six-week interval on two occasions was 0.74. This correlation coefficient indicates a short-term variation of serum cholesterol, and reflects measurement errors and intra-individual fluctuations in cholesterol level, eg due to variations in dietary habits. The correlation coefficient for serum cholesterol values taken with a two-year interval was 0.66 and reflects a long-term variation. The ratio between these coefficients may be interpreted as a rough estimate of a correlation between the true cholesterol levels at a two-year interval, free from measurement errors and short-term intraindividual variations in dietary habits. The validity was assessed with the correlation between a single serum cholesterol value and mortality from myocardial infarction, in a cohort of 92 839 individuals followed-up for 14–16 years. The relative risks (RR) for death in myocardial infarction increased with increasing cholesterol levels. The RRs were in accordance with the well-established correlation between serum cholesterol and death from myocardial infarction. The results indicated a fairly high stability of the cholesterol level in blood and that the choiesterol values in the studied cohort were not less reliable then in comparable studies.
Revised 1 April 1988
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