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© 1988 Oxford University Press

research-article

A Prospective Study of the Relation Between Smoking and Fertility

J DE MOUZON, A SPIRA and D SCHWARTZ

INSERM U 292, Hopital de Bicetre, 78, rue du General Lederc 94275 Le Kremlin Bicetre Cedcx, France

A prospective study of fertility was conducted from 1977 to 1982. Analysis of the relation between cigarette smoking and occurrence of a pregnancy was performed on 1887 couples. The actuarial pregnancy rate was 82.9% at the end of a year. Cigarette smoking by both members of the couple was found to be related to decreased fertility when this factorwas considered alone. But after including all the confounding covariates in a Cox semi-proportional hazards model for survival data, no relationship remained between cigarette smoking and fertility. Odds ratios were respectively 0.86 (95% confidence interval: 0.63, 1.19) and 0.99 (0.85, 1.14) for women smoking and men smoking. This could suggest that the relationship found by other authors might be at least partly explained by a relation between cigarette smoking and other factors related to fertility.

Revised 1 February 1987


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