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© 1987 Oxford University Press

research-article

The Relationship between Smoking and the Response to Anti-Hypertensive Treatment in Mild Hypertensives in the Medical Research Council's Trial of Treatment

GILLIAN GREENBERG, S G HOMPSON and P J BRENNAN

MRC Epidemiology and Medical Care Centre, Northwick Park Hospital Watford Road, Harrow, Middx HAI 3UJ, UK

Present address: Department of Environmental and Preventive Medicine, The Medical College of St Bartholomew's Hospital, Charterhouse Sq, London ECIM 6BQ, UK.

The antihypertensive efficacy of propranolol in the treatment of mild hypertension was significantly impaired in cigarette smokers, whereas that of bendrofluazide was not affected by smoking habit. This diminished efficacy of propranolol in smokers may be one of several possible factors operating to reduce its primary preventive action against strokes, and possibly against coronary events.

Received 1 August 1986


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