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© 1986 Oxford University Press

other

Cohort Study Analysis with a FORTRAN Computer Program

MICHEL COLEMAN*, ALLISON DOUGLAS**, CAROL HERMON* and JULIAN PETO{dagger}

*Imperial Cancer Research Fund, Cancer Epidemiology and Clinical Trials Unit Gibson Building, Radcliffe Infirmary, Oxford OX2 6HE, UK
* *Dept of Epidemiology, London School of Hygiene & Tropical Medicine Keppel Street, London WC1E 7HT, UK
{dagger}Institute of Cancer Research, Division of Epidemiology Block D, Clifton Avenue, Sutton, Surrey SM2 5PX, UK

We describe the analysis of cohort study data with a standard FORTRAN program which should run on most computers. It provides a summary measure of the mortality (or incidence) rate ratio between the study cohort and some standard population, based either on person-years at risk or on proportional mortality, and adjusted for age, sex and calendar period; a test of the statistical significance of the ratio; and a set of observed death rates in the study cohort. Results may also be produced in a form suitable for use with GLIM. The analysis may be subdivided into a range of time intervals since each subject was first exposed to risk. The program provides for movement of subjects between different ‘level-of-exposure’ subgroups within the cohort, and for various methods of censoring. It allows considerable flexibility in data management, and is available with complete documentation and a worked example. The program should enable epidemiologists with little computing experience to carry out formal analysis of cohort studies.

Received 1 June 1985


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