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© 1983 Oxford University Press

research-article

Genetic and Environmental Determinants of Cholesterol and HDL-Cholesterol Concentrations in Blood

G DAHLÉN*, C ERICSON*, U de FAIRE{dagger}, L ISELIUS{ddagger} and T LUNDMAN{dagger}

*Laboratory of Clinical Chemistry, Central Hospital Boden, Sweden
{dagger}Department of Medicine, Scrafimerlasarettet Stockholm, Sweden
{ddagger}Department of Clinical Genetics, Karolinska Hospital, Stockholm, Sweden and Population Genetics Laboratory, University of Hawaii Honolulu, Hawaii, USA

Serum cholesterol and HDL-cholesterol have been studied in 274 Swedish nuclear families. The families were ascertained through the Swedish twin registry and consisted of married mono- and dizygous twins, their spouses and with at least one adult child. Total cholesterol was determined using an enzymatic colorimetric method and HDL-cholesterol by the heparin-manganese chloride precipitation method. The genetic analysis was performed using a path analytic model to resolve genetic and cultural heritability, marital correlations and maternal effects. Genetic heritability was 0.50 and 0.37 for total cholesterol and HDL-cholesterol, respectively. Cultural heritability was small, 0.04, for cholesterol but substantial 0.22. for HDL-cholesterol. A maternal effect was evident for cultural inheritance for HDL-cholesterol but not for cholesterol.

Received 1 April 1982


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