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© 1983 Oxford University Press

research-article

Relation of Serum Cholesterol and Triglycerides to the Risk of Acute Myocardial Infarction, Cerebral Stroke and Death in Eastern Finnish Male Population

JUKKA T SALONEN* and PEKKA PUSKA{dagger}

*North Karelia Project, Research Institute of Public Health, University of Kuopio Box 40, 70101 Kuopio 10, Finland
{dagger}Department of Epidemiology, National Public Health Institute Mannerheimintie 166, 00280 Helsinki 28, Finland

A random population sample from two counties of eastern Finland was studied in 1972. measuring eg the serum total cholesterol and triglycerides, blood pressure, and smoking. The participation rate among men aged 30 to 59 was 92%. Men who had had a myocardial infarction, angina or cerebral stroke in the preceding 12 months were excluded. During the seven-year follow-up 211 men had an acute myocardial infarction (AMI). 59 men had a cerebral stroke and 185 men died of any disease.

The serum total cholesterol (≥8.0 mmol/l) had a positive association with the risk of AMI (relative risk RR=2.8, 95% CI=1.8–4.3) and the risk of death (RR=2.2, 95% CI=1.3–3.7) among men aged 30–49 but only with the risk of AMI (RR=2.0, 95% CI=1.3–3.1) among those aged 50–59 based on multiple logistic models including also age, serum triglycerides, diastolic blood pressure, smoking and obesity. Serum triglycerides ( mmol/l) had a positive risk factor-adjusted association with the risk of cerebral stroke (RR=2.7, 95% CI=1.0–7.1) among men aged 30–49, but no independent association with the risk of AMI or death.

Received 1 May 1982


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