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© 1982 Oxford University Press

research-article

A Women's Birth Cohort Effect on Malformation Rates

BENGT KÄLLÉN* and STEN LINDHAM{dagger}

* Department of Embryology, University of Lund, Biskopsgatan 7, S-223 62 Lund, Sweden
{dagger} Department of Children's Surgery, S:t Göran Hospital, Stockholm, Sweden

Källé n, B (Department of Embryology, Biskopsgatan 7, S-223 62 Lund, Sweden) and Lindham, S. A women's birth cohort effect on malformation rates. International Journal of Epidemiology 11:398ndash;401.

A relatively sudden increase in prevalence at birth of gastroschisis was seen in Sweden at the beginning of the 1970s. Case-control studies, looking for a teratogenic factor, have proved negative. This paper presents a hypothesis suggesting that the women's birth cohort has an effect: women born in 1953–5 have an increased probability of having this type of malformed infants. A computer simulation is made indicating that the actually recorded facts can, at least in part, be explained by the hypothesis.

Received 1 March 1982


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