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© 1981 Oxford University Press

research-article

Chloracne Following Environmental Contamination by TCDD in Seveso, Italy

F CARAMASCHI*, G DEL CORNO**, C FAVARETTI*, S E GIAMBELLUCA{dagger}, E MONTESARCHIO** and G M FARA**

*Istituto di Igiene Università di Padova, Via Loredan18, 35100 Padova Italy
**Istituto di Igiene Università di Milano, OspedalePoliclinico, Via F Sforza 35, 20122 Milano Italy
{dagger}Istituto di Igiene Università di Palermo, Via Vespro133, Palermo Italy

Caramaschi F [Istituto di Igiene Università di Padova, Via Loredan 18, 35100 Padova, Italy], Del Corno G, Favaretti C, Giambelluca SE, Montesarchio E and Fara GM. Chloracne following environmental contamination by TCDD in Seveso, Italy.International Journal of Epidemiology 1981, 10: 135–143.

Data are presented on the occurrence of chloracne, clinical symptoms and biochemical changes in 164 children following environmental contamination by TCDD from an industrial accident in Seveso, Italy. An overall positive association was found between the territorial distribution of chloracne cases and the different levels of soil contamination in the affected area. Individual risk factors such as condition and length of exposure, intake via contaminated foods, etc. were evaluated; no single factor appeared to be associated with chloracne. Disturbances of the gastrointestinal tract were more frequently observed in children affected with chloracne than in those from the same areas having no skin lesions. However, no clinically definable systemic disease has been diagnosed.

Revised 11 July 1980


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