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© 1981 Oxford University Press

research-article

Plasmodium Falciparum Malaria and Human Red Cells. II. Red Cell Genetic Traits and Resistance Against Malaria

IRENE GUGGENMOOS-HOLZMANN*, ULRICH BIENZLE* * and LUCIO LUZZATTO{dagger}

*Department of Statistics, University of Erlangen Germany
* *Bernhard-Nocht-Institut für Schiffs- und Tropenkrankheiten, Department of Medicine Hamburg, Germany
{dagger}International Institute of Biophysics and Genetics Via Marconi 10, Casella Postale 3061, Naples 80125, Italy

Guggenmoos-Holzmann I (Department of Statistics, University of Erlangen, Germany), Bienzle U and Luzzatto L. Plasmodium falciparum malaria and human red cells. II Red cell gentic traits and resistance against malaria. International Journal of Epidemiology 1981, 10: 16–22.

In 702 Nigerian children under 6 years of age the incidence and the severity of malarial infection was studied with respect to heamoglobin types and red cell glucose-6-phosphate dehydrogenase variants. The results suggest that Hb AS as well as the female genotype GdA–1GdB offer selective advantage against the disesse. Paresite densities in carriers of these genotypes were significantly lower than in other subjects. Whereas protection by Hb AS was found mainly in children between 2 and 4 years of age, the advantage afforded by GdA–1GdB was similar in all age groups. Possible mechanisms are discussed.

Received 20 October 1980


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