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IJE Advance Access published online on October 1, 2009
International Journal of Epidemiology, doi:10.1093/ije/dyp298
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Published by Oxford University Press on behalf of the International Epidemiological Association © The Author 2009; all rights reserved.. The online version of this article has been published under an open access model. Users are entitled to use, reproduce, disseminate, or display the open access version of this article for non-commercial purposes provided that: the original authorship is properly and fully attributed; the Journal and Oxford University Press are attributed as the original place of publication with the correct citation details given; if an article is subsequently reproduced or disseminated not in its entirety but only in part or as a derivative work this must be clearly indicated. For commercial re-use, please contact journals.permissions@oxfordjournals.org

Commentary: Raising the bar on telomere epidemiology

Abraham Aviv

The Center of Human Development and Aging, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, NJ 07103, USA. E-mail: avivab@umdnj.edu

Accepted 3 August 2009

The first 10% of the full text of this article appears below.

Ehrlenbach and co-workers1 report, in this issue of the International Journal of Epidemiology, findings of a longitudinal, population-based study in 510 individuals. They observed that individuals who died during a 10-year follow-up had shorter relative telomere length (RTL), measured by quantitative polymerase chain reaction (qPCR), than those who survived. They also confirmed from the previous work that the rate of leucocyte telomere length (LTL) shortening was proportional to baseline LTL.2

Though a controversy had existed about whether LTL predicts survival in the elderly,3,4 more recent studies in same-sex elderly twins5,6 showed that the co-twin with the shorter LTL was likely to . . . [Full Text of this Article]


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