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IJE Advance Access published online on July 7, 2009
International Journal of Epidemiology, doi:10.1093/ije/dyp228
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Published by Oxford University Press on behalf of the International Epidemiological Association © The Author 2009; all rights reserved.

Commentary: A new dawn for genetic epidemiology?

Timothy M Frayling

Department of Genetics of Complex Traits, Peninsula College of Medicine and Dentistry, University of Exeter, Exeter EX1 2LU, UK. E-mail: tim.frayling@pms.ac.uk

Accepted 14 May 2009

The first 10% of the full text of this article appears below.

Genome-wide association studies (GWAS) have resulted in an unprecedented leap in our understanding of the common genetic variation associated with common diseases and traits. Work performed predominantly in the last 2 years means there are now more than 200 common DNA variants associated with human traits, at levels of statistical significance, which means less than 1 in 20 will be false positives. This contrasts with the situation before 2006, where, in total, less than 20 common variant–trait associations was considered robust.

Despite this progress, GWAS studies have been recently criticized as not providing the biological or clinical insight predicted.1,2 Some commentators have suggested that the associations between a single base-pair change and a human trait or disease have not told us . . . [Full Text of this Article]


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