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IJE Advance Access published online on April 22, 2008
International Journal of Epidemiology, doi:10.1093/ije/dyn072
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Published by Oxford University Press on behalf of the International Epidemiological Association © The Author 2008; all rights reserved.

Cohort Profile: The STRIP Study (Special Turku Coronary Risk Factor Intervention Project), an Infancy-onset Dietary and Life-style Intervention Trial

Olli Simell1, Harri Niinikoski1,*, Tapani Rönnemaa2, Olli T Raitakari3,4, Hanna Lagström5, Maarit Laurinen4, Minna Aromaa6, Paula Hakala7, Antti Jula8, Eero Jokinen9, Ilkka Välimäki1, Jorma Viikari2 and for the STRIP Study Group

1 Department of Pediatrics, University of Turku, Turku, Finland.
2 Department of Medicine, University of Turku, Turku, Finland.
3 Department of Clinical Physiology, University of Turku, Turku, Finland.
4 Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.
5 Turku Institute for Child and Youth Research, University of Turku, Turku, Finland.
6 City of Turku Health Care, Turku, Finland.
7 Social Insurance Institution, Turku, Finland.
8 National Public Health Institute, Turku, Finland.
9 Department of Pediatrics, University of Helsinki, Helsinki, Finland.

* Corresponding author. Department of Pediatrics, University of Turku, Kiinamyllynkatu 4-8, 20520 Turku, Finland. E-mail: harri.niinikoski@tyks.fi

Accepted 19 March 2008

The first 150 words of the full text of this article appear below.


   How did the study come about?
 
It is now clear that atherosclerosis develops as a result of a life-long process often leading to coronary heart disease.1 Nutritional recommendations have been delivered to the general community to manage this epidemic. Since fat is an important source of energy and cholesterol is required for sex hormone synthesis, fears have emerged that low intake of saturated fat and cholesterol might influence children's growth and development. Infants and young children have therefore been excluded from these nutritional recommendations.2 However, a number of arguments support the concept that prevention of children's exposure to atherosclerosis risk factors should be started at an early age. Dietary fat intake and quality of fat regulate serum lipoprotein values in childhood in the same way as they do in adults.3,4 It has also been shown that children with high serum cholesterol and LDL cholesterol values are predisposed to early atherosclerotic changes in aorta and large arteries5,6 . . . [Full Text of this Article]


   What does STRIP cover?
 

   Who is the sample?
 

   What kind of counselling is given to STRIP intervention children?
 

   What has been measured?
 

   What is attrition like?
 

   What has been found? Main findings and publications
 

   What are the main strengths and weaknesses of STRIP study?
 

   Where can I find out more?
 

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