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IJE Advance Access originally published online on February 8, 2008
International Journal of Epidemiology 2008 37(5):948-955; doi:10.1093/ije/dym231
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Published by Oxford University Press on behalf of the International Epidemiological Association © The Author 2008; all rights reserved.

Cohort profile: the Centers for AIDS Research Network of Integrated Clinical Systems

Mari M Kitahata1,*, Benigno Rodriguez2, Richard Haubrich3, Stephen Boswell4, W Christopher Mathews3, Michael M Lederman2, William B Lober1, Stephen E Van Rompaey1, Heidi M Crane1, Richard D Moore5, Michael Bertram6, James O Kahn7 and Michael S Saag6

1 Department of Medicine, University of Washington, Seattle, 98195, USA.
2 Department of Medicine, Case Western Reserve University, Cleveland, 44106, USA.
3 Department of Medicine, University of California, San Diego, 92110, USA.
4 Department of Medicine, Harvard University, Boston, 02115, USA.
5 Department of Medicine, Johns Hopkins University, Baltimore, 21218, USA.
6 Department of Medicine, University of Alabama, Birmingham, 35209, USA.
7 Department of Medicine, University of California, San Francisco, 94143, USA.

* Corresponding author. Center for AIDS Research, University of Washington, 325 9th Ave, MS 359931, Seattle, WA 98104, USA. E-mail: kitahata@u.washington.edu

Accepted 17 October 2007

The first 150 words of the full text of this article appear below.


   How did the study come about?
 
Highly active antiretroviral therapy (HAART) delays disease progression and death.1–4 However, the treatments incompletely control HIV replication,5–7 only partially restore immune function,8,9 have significant short- and long-term toxicities,10–14 and eventually fail in many patients with consequent development of HIV drug resistance.6 Thus, there is increasing need for information to guide HIV-infected patients and their providers in making decisions regarding optimal use of antiretroviral therapies. Although clinical trials provide valuable information about efficacy and side effects of antiretroviral treatment, they have limited size, duration and power to detect effects on clinical outcomes, focusing instead on surrogate endpoints such as virologic failure, treatment discontinuation or composite outcome measures.15

Outside the clinical trial setting, there is tremendous heterogeneity among HIV-infected patients. The prevalence and impact of important health conditions such as hepatitis C virus (HCV) co-infection, mental illness and substance abuse likely contribute to increased toxicity and decreased clinical effectiveness of HAART regimens . . . [Full Text of this Article]


   What does it cover and who is in the sample?
 

   How often have they been followed up and what is the attrition rate?
 

   What has been measured?
 

   What has been found? Key findings and publications
 

   What are the main strengths and weaknesses?
 

   How can I collaborate? Where can I find out more?
 
Process for new collaborators
Process for adding new collaborating cohorts

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