IJE Advance Access originally published online on November 12, 2007
International Journal of Epidemiology 2008 37(3):474-480; doi:10.1093/ije/dym216
Published by Oxford University Press on behalf of the International Epidemiological Association © The Author 2007; all rights reserved.
Cohort Profile: The Paediatric Antiretroviral Treatment Programmes in Lower-Income Countries (KIDS-ART-LINC) Collaboration
Elise Arrivé1,
Daniel J Kyabayinze2,
Benoit Marquis1,
Nathan Tumwesigye2,
Mary-Pat Kieffer3,
Alain Azondekon4,
Louise Wemin5,
Patricia Fassinou6,
Marie-Louise Newell7,
Valériane Leroy1,
Elaine J Abrams8,
Mark Cotton9,
Andrew Boulle10,
Dorothy Mbori-Ngacha2,
François Dabis1,* and
for the KIDS-ART-LINC Collaboration
1 Unité INSERM 593, Institut de Santé Publique, Epidémiologie et Développement (ISPED), Université Victor Segalen, Bordeaux, France.
2 African Network for the Care of Children Affected by AIDS (ANECCA), Kampala, Uganda.
3 USAID, Nairobi, Kenya.
4 Unité de Prise en charge des enfants Exposé ou Infecté au VIH (UPEIV)/Hôpital d’Instruction des Armées (HIA), Cotonou, Bénin.
5 CEPREF Enfants, Abidjan, Côte d’Ivoire.
6 Centre Hospitalier Universitaire de Yopougon, Abidjan, Côte d’Ivoire.
7 Centre for Paediatric Epidemiology and Biostatistics, Institute of Child Health, University College London, UK and Africa Centre for Health and Population Studies, University of KwaZulu Natal, Somkhele, South Africa.
8 Mailman School of Public Health, Columbia University, New York, NY, USA.
9 Department of Paediatrics and Child Health, Tygerberg Children's Hospital, Univeristy of Stellenbosch, Cape Town, South Africa.
10 School of Public Health and Family Medicine, University of Cape Town, South Africa.
* Corresponding author. INSERM U.593 – ISPED (Case 11), Université Victor Segalen Bordeaux 2, 33076 BORDEAUX Cedex, France. E-mail: Francois.dabis@isped.u-bordeaux2.fr
Accepted 25 September 2007
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How did the study come about?
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The Paediatric Antiretroviral Treatment Programmes in Lower-Income
Countries (KIDS-ART-LINC) collaboration (see Appendix for details)
is an international epidemiological network in sub-Saharan Africa.
The paediatric HIV burden is currently estimated at 2.3 million
(1.7–3.5 million) children under 15 years of age worldwide,
90% of them living in sub-Saharan Africa.
1 Anti-retroviral therapy
(ART) is an essential part of the overall strategy to fight
the HIV pandemic, and has, since 1996, led to substantial reduction
in HIV-related morbidity and mortality in children in industrialized
nations.
2,3 However, paediatric HIV care and ART programmes
have not reached most resource-poor settings, particularly in
Africa. Simplified models, developed to deliver drugs to large
numbers of people generally focus on adults and have rarely
addressed ART in children.
4 An estimated 780 000 children were
in need of ART in 2006 and only 10% of them received it.
5 The
World Health Organization (WHO) has recently updated its guidelines
for
. . . [Full Text of this Article]
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What does it cover?
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Who is in the sample?
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How often have children been followed-up?
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What has been measured?
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What is the attrition like?
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What has been found? Key findings and publications
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What are the main strengths and weakness?
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Can I get hold of the data? Where can I find out more?
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Appendix
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The KIDS-ART-LINC Collaboration is organized as follows
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