IJE Advance Access originally published online on September 10, 2007
International Journal of Epidemiology 2007 36(5):969-976; doi:10.1093/ije/dym073
Published by Oxford University Press on behalf of the International Epidemiological Association © The Author 2007; all rights reserved.
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Cohort Profile: Caribbean, Central and South America Network for HIV research (CCASAnet) collaboration within the International Epidemiologic Databases to Evaluate AIDS (IeDEA) programme
Catherine C McGowan1,*,
Pedro Cahn2,
Eduardo Gotuzzo3,
Denis Padgett4,
Jean W Pape5,
Marcelo Wolff6,
Mauro Schechter7 and
Daniel R Masys1
1Vanderbilt University School of Medicine, Nashville, TN, USA.
2Fundación Huésped and Hospital Fernández, Buenos Aires, Argentina.
3Universidad Peruana Cayetano Heredia Facultad de Medicina and Instituto de Medicina Tropical Alexander von Humboldt, Lima, Peru.
4Instituto Hondureño de Seguridad Social and Universidad Autonoma de Honduras, Tegucigalpa, Honduras.
5Les Centres GHESKIO, Port-au-Prince, Haiti.
6Fundación Arriarán and Facultad de Medicina, Universidad de Chile, Santiago, Chile.
7Projeto Praça Onze, Hospital Universitário Clementino Fraga Filho and Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
* Corresponding author. Division of Infectious Diseases, Vanderbilt University School of Medicine, 345 24th Avenue North, Suite 103, Nashville, TN 37203, USA. E-mail: c.mcgowan@vanderbilt.edu
Accepted 20 March 2007
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How did the study come about?
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The HIV/AIDS epidemic has evolved in its third decade to be
an unprecedented human catastrophe of global scale and importance.
Although an historic response for change and intervention has
led to decreased rates of new infections and HIV-associated
mortality in many communities, the enormity of the pandemic
continues to overwhelm already constrained resources everywhere.
Improved understanding of antiretroviral therapy (ART) responses
and viral and host characteristics, both within and between
diverse settings and populations, is needed to guide initiatives
in HIV prevention and treatment worldwide.
The merging of existing clinical and research data related to HIV infection and its associated disorders answers questions that currently cannot be addressed using randomized trials or single sources of data. Cohorts such as MACS,1 WIHS,2 HIVRN,3 EuroSida and the Swiss HIV Cohort4–6 have produced important observations regarding the epidemiology and long-term outcomes of HIV-infected individuals residing in North America and Europe, both before and . . . [Full Text of this Article]
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The IeDEA initiative
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CCASAnet core aims, organization and scientific agenda
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What does it cover and who is in the sample?
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How often have patients been followed-up and what is measured?
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What is the attrition rate likely to be?
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What protection of human subjects is used?
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What are the main strengths and weaknesses of CCASAnet?
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How can I collaborate? Where can I find out more?
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Supplementary material
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Appendix
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