IJE Advance Access originally published online on January 25, 2007
International Journal of Epidemiology 2007 36(4):724-730; doi:10.1093/ije/dyl299
Published by Oxford University Press on behalf of the International Epidemiological Association © The Author 2007; all rights reserved.
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Cohort Profile: The International Childhood Cancer Cohort Consortium (I4C)
Rebecca C Brown1,*,
Terence Dwyer2,
Carol Kasten3,
Danuta Krotoski4,
Zhu Li5,
Martha S Linet3,
Jørn Olsen6,
Peter Scheidt4,
Deborah M Winn3 for the International Childhood Cancer Cohort Consortium (I4C)
1 National Center for Environmental Assessment, Office of Research and Development, U.S. Environmental Protection Agency, Washington, DC, USA.
2 Murdoch Childrens Research Institute, Melbourne, Australia.
3 National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD, USA.
4 National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Rockville, MD, USA.
5 National Center for Maternal and Infant Health, Peking University Health Science Center, Beijing, China.
6 Department of Epidemiology, University of California, Los Angeles, CA, USA.
* Corresponding author. U.S. Environmental Protection Agency, National Center for Environmental Assessment, 1200 Pennsylvania Avenue, NW, 8623D, Washington, DC, 20460 USA. E-mail: brown.rebecca@epa.gov
Accepted 7 December 2006
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How did the study come about?
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Globally, a number of large infant/child prospective studies
have been launched to examine environmental and genetic determinants
of common diseases of children, such as asthma, developmental
delay and behaviour abnormalities, as well as the consequences
of early exposure for adult diseases. While several of these
studies are relatively very large—over 100 000 subjects—and
are adequately powered to examine their principal outcomes of
interest, none of the individual studies are of sufficient size
to examine the relationship between exposures they are measuring
and rare diseases such as childhood cancer. To date, the few
established risk factors for specific forms of childhood cancer
have largely been identified in case-control studies. Yet, despite
many such investigations evaluating postulated risk factors
for paediatric malignancies during the past five decades, few
consistently established aetiologic factors are known. Recent
review papers
1–4 have summarized many promising hypotheses,
including pre-natal and post-natal exposure to pesticides, maternal
and early
. . . [Full Text of this Article]
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What does it cover?
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Who is in the sample?
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How often have they been followed up?
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What will be measured?
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What is the anticipated attrition?
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What will be the major areas of research?
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Chromosomal RearrangementsFolic Acid Supplementation and Genetic Polymorphisms
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What are the main strengths and weaknesses?
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Can I get access to the data? Where can I find out more?
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