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IJE Advance Access originally published online on April 17, 2007
International Journal of Epidemiology 2007 36(2):285-287; doi:10.1093/ije/dym053
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Published by Oxford University Press on behalf of the International Epidemiological Association © The Author 2007; all rights reserved.

Commentary: On the incidence of histological prostate cancer and the probable diagnosis of cases with tumours too small to produce symptoms or to attract attention on physical examination—the findings of Dr Arnold Rice Rich

Jan Adolfsson

Oncologic Centre, Karolinska University Hospital, CLINTEC, Karolinska Institute, Stockholm, Sweden.

E-mail: jan.adolfsson@karolinska.se

Keywords Prostate cancer, histological rate, latent cancer, insignificant cancer

Accepted 5 December 2006

The first 150 words of the full text of this article appear below.

In 1935, Dr Arnold Rice Rich, pathologist, wrote the following:

‘For a number of years the writer has been impressed by the frequency of the small carcinomas that have been found in the prostate in the routine autopsy material of this department (Department of Pathology, John's Hopkins Medical School, Maryland, USA)’.1

The background of this observation was an investigation of the incidence of prostate cancer in a series of 2000 autopsy cases. Of these cases, 292 were male, aged 50 years or older. The prostates of these 292 males were investigated routinely macroscopically and microscopically with one block taken from each prostate. The blocks were taken at palpable lesions or randomly if no obvious macroscopic lesion could be found. Although this procedure is nowhere near today's serial sections of the specimens from radical prostatectomies, Dr Rice Rich found primary prostate cancer in 41 (14%) of the 292 specimens. In 14 . . . [Full Text of this Article]


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