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IJE Advance Access originally published online on April 27, 2006
International Journal of Epidemiology 2006 35(3):520-525; doi:10.1093/ije/dyl062
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Published by Oxford University Press on behalf of the International Epidemiological Association © The Author 2006; all rights reserved.

Reprints and Reflections

The analysis of variance and the analysis of causes

R C LEWONTIN*

Museum of Comparative Zoology, Harvard University, Cambridge, Massachusetts 02138, USA

The first 150 words of the full text of this article appear below.

This issue of the American Journal of Human Genetics contains two articles by Newton Morton and his colleagues1,2 that provide a detailed analytic critique of various estimates of heritability and components of variance for human phenotypes. They make especially illuminating remarks on the problems of partitioning variances and covariances among groups such as social classes and races. The most important point of all, at least from the standpoint of the practical, social, and political applications of human population genetics, occurs at the conclusion of the first paper1 in which Morton points out explicitly the chief programmatic fallacy committed by those who argue so strongly for the importance of heritability measures for human traits. The fallacy is that a knowledge of the heritability of some trait in a population provides an index of the efficacy of environmental or clinical intervention in altering the trait either in individuals or in the population . . . [Full Text of this Article]


   Discrimination of causes and analysis of causes
 

   Quantitative analysis of causes
 

   Norm of reaction
 

   Effect of additivity
 

   Purpose of analysis
 

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