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IJE Advance Access originally published online on April 17, 2006
International Journal of Epidemiology 2006 35(3):507-510; doi:10.1093/ije/dyl071
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International Journal of Epidemiology 2006;35:507-510
© International Epidemiological Association 2006

Editorial Statement

Make it HuGE: human genome epidemiology reviews, population health, and the IJE

George Davey Smith1,*, Marta Gwinn2, Shah Ebrahim3, Lyle J Palmer4 and Muin J Khoury2

1 Department of Social Medicine, University of Bristol, BS8 2PR, UK
2 Centers for Disease Control and Prevention, Atlanta, GA, USA
3 London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK
4 Western Australia Institute for Medical Research, Perth, Australia

* Corresponding author. E-mail: george.davey-smith@bristol.ac.uk

The first 150 words of the full text of this article appear below.

The International Journal of Epidemiology is concerned with scientific evidence that can ultimately form the basis of strategies for improving population health. Hence, the IJE would be expected to remain cautious about the technological advances heralded by the sequencing of the human genome. The classical epidemiological approaches of examining secular trends in disease risk, changes in risk consequent upon migration, and differences in disease rates between populations indicate that little of the global burden of common disease can be attributed to simple differences in genetically determined risk. It is not surprising that many social epidemiologists and public health practitioners (including, in the past, some of the authors of this editorial) have pointed this out. More surprising, perhaps, is that in the spirit of honest accounting, some geneticists and genetic epidemiologists have also punctured the inflated claims of genetic epidemiology by emphasizing that the population-attributable risk of most common genetic variants . . . [Full Text of this Article]


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