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IJE Advance Access originally published online on November 22, 2005
International Journal of Epidemiology 2006 35(2):224-225; doi:10.1093/ije/dyi232
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Published by Oxford University Press on behalf of the International Epidemiological Association © The Author 2005; all rights reserved.

Commentary

Commentary: Time for public health action on vitamin D for cancer risk reduction

William B Grant1 and Edward D Gorham2,3,*

1 Sunlight, Nutrition and Health Research Center (SUNARC), 2107 Van Ness Avenue, Suite 403B, San Francisco, CA 94109-2529, USA.
2 Department of Family and Preventive Medicine, University of California, San Diego, 9500 Gilman Drive 0631C, La Jolla, CA 92093, USA.
3 Naval Health Research Center, San Diego, CA 92186-5122, USA.

* Corresponding author. E-mail: Gorham@nhrc.navy.mil

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The seminal paper by Garland and Garland1 continues the tradition of observation and inference leading the way to discovery of new methods for preventing or curing disease. Their paper broke ground by marshalling the evidence for the vitamin D-cancer hypothesis. Their work directly confronted the prevailing paradigms that the main risk factors for colon cancer were deficient fibre intake, excessive fat intake, and/or genetic predisposition.

At that time it was hard to envision that a geophysical characteristic, such as solar ultraviolet-B (UVB) radiation, through photosynthesis of vitamin D, would reduce cancer risk. Solar UVB was . . . [Full Text of this Article]


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