IJE Advance Access originally published online on September 29, 2005
International Journal of Epidemiology 2006 35(1):42-48; doi:10.1093/ije/dyi202
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Published by Oxford University Press on behalf of the International Epidemiological Association © The Author 2005; all rights reserved.
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Cohort profile: The Southampton Women's Survey
1 MRC Epidemiology Resource Centre, University of Southampton, Southampton General Hospital, Southampton SO16 6YD, UK
2 Centre for Paediatric Epidemiology and Biostatistics, Institute of Child Health, University College London, 30 Guilford Street, London WC1N 1EH, UK
3 Centre for Developmental Origins of Health and Disease, University of Southampton, Mailpoint 887, Princess Anne Hospital, Coxford Road, Southampton SO16 5YA, UK
* Corresponding author. E-mail: hmi@mrc.soton.ac.uk
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How did the study come about? |
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Inverse associations between birthweight and later risk of major chronic diseases, notably cardiovascular disease, diabetes, and osteoporosis, have been found in various studies.1 Birthweight is determined by length of gestation and the combination of the early trajectory of fetal growth and the capacity of the fetal supply line to maintain this trajectory in late gestation. Studies in early pregnancy, assisted reproductive technology, and animal experiments indicate that both genetic and environmental factors are important in establishing the fetal growth trajectory and the fetal supply line; environmental factors include transgenerational influences and the mother's body composition, endocrine profile, diet, and physical activity around the time of conception.2 As these influences may change during early pregnancy, there is a need to characterize women before conception. The Southampton Women's Survey (SWS) was thus established to measure the pre-pregnant characteristics of women aged 20–34 years living in the city and then follow-up those women
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What does it cover? |
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Who is in the sample? |
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How often have they been followed-up? |
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What has been measured? |
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What is attrition like? |
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What has it found? |
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What are the main strengths and weaknesses? |
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Where can I find out more and what is the potential for collaboration? |
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