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IJE Advance Access originally published online on May 27, 2004
International Journal of Epidemiology 2004 33(5):953-954; doi:10.1093/ije/dyh217
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IJE vol.33 no.5 © International Epidemiological Association 2004; all rights reserved.

Commentary

Commentary: Twins, low birthweight and type 2 diabetes

DIW Phillips

MRC Unit, Southampton General Hospital, Tremona Road, Southampton SO16 4YD, UK. E-mail: diwp@mrc.soton.ac.uk

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One of the important issues raised by the fetal origins hypothesis is the extent to which the associations between birthweight and adult health outcomes, such as type 2 diabetes, are explained by common genetic factors, or are a result of fetal programming by the early environment. Indeed, a genetic explanation has been specifically proposed for the association between birthweight and type 2 diabetes.1 In pathophysiological terms this is logical. Since insulin has a central role in controlling fetal growth, genetic factors which impair insulin secretion . . . [Full Text of this Article]


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