IJE Advance Access originally published online on May 27, 2004
International Journal of Epidemiology 2004 33(5):929-935; doi:10.1093/ije/dyh231
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IJE vol.33 no.5 © International Epidemiological Association 2004; all rights reserved.
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Epigenetic epidemiology
The Cohn Institute for the History and Philosophy of Science and Ideas, Tel-Aviv University, Tel-Aviv 69978, Israel. E-mail: jablonka@post.tau.ac.il
| The first 150 words of the full text of this article appear below. |
Traditionally, when a disease persists in a population over several generations, it is attributed either to genetic continuity (the inheritance of defective genes) or to environmental continuity (the persistence of adverse conditions or infectious agents). However, during the last two decades, there has been an accumulation of observations that do not slot neatly into either of these categories. It has become clear that the health and general physiology of animals and people can be affected not only by the interplay of their own genes and conditions of life, but also by the inherited effects of the interplay of genes and environment in their ancestors. These ancestral influences on health depend neither on inheriting particular genes, nor on the persistence of the ancestral environment.
The studies that have revealed heritable effects that do not depend on DNA sequence variations have used several different methodologies and had a variety of aims. Some
| Epigenetic inheritance systems (EIS) |
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| Epigenetic inheritance and human health |
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| Transgenerational epigenetic inheritance |
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| Where do we go from here? |
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| Glossary |
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