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International Journal of Epidemiology 2003;32:58-59
© International Epidemiological Association 2003

Special Theme: Genetic Epidemiology

Commentary: Balancing quantity and quality when designing epidemiological studies

Andrew Phillips

Royal Free Centre for HIV Medicine & Department of Primary Care & Population Sciences, Royal Free & University College Medical School, University College London, London, UK.

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The increasing identification of genetic factors which predispose people to higher risk of certain diseases will reinvigorate the epidemiology of such diseases and provide new challenges for study design. Some of these design issues are addressed in the paper in this issue of the International Journal of Epidemiology by Wong et al., which provides a useful formula for calculating sample size estimates for detecting gene–environment interactions for continuous traits.1 An example of such a potential interaction —used in the paper—is where a study aims to see if the association between physical . . . [Full Text of this Article]


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Int. J. Epidemiol., February 1, 2003; 32(1): 1 - 22.
[Abstract] [Full Text] [PDF]