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International Journal of Epidemiology 2002;31:23-26
© International Epidemiological Association 2002

Reprints and Reflections

Commentary: The unresolved mystery of birth-cohort phenomena in gastroenterology

Amnon Sonnenberg, Claudia Cucino and Peter Bauerfeind

The Department of Veterans Affairs Medical Center, and The University of New Mexico, Albuquerque, New Mexico, USA.

Amnon Sonnenberg, Department of Veterans Affairs Medical Center 111F, 1501 San Pedro Drive SE, Albuquerque, New Mexico 87108, USA. E-mail: sonnbrg@unm.edu

In the landmark paper written by Mervyn Susser and his wife Zena Stein, it was shown that the temporal trends of peptic ulcer were more closely related to the time of birth of individual ulcer patients than to the time when they contracted their ulcer and died from it.1 When the original paper was published in The Lancet in 1962, the overall frequency of gastric and duodenal ulcer were still rising in the British population. The British birth-cohorts born between 1870 and 1890 carried the highest risk of developing gastric and duodenal ulcer, respectively. As these cohorts grew older and their general age-related mortality increased, the overall number of deaths associated with bleeding and perforated peptic ulcers was still rising in the population. Susser and Stein speculated that eventually, as these high-risk cohorts grew older and their proportion in the population declined, the occurrence and mortality of peptic ulcer would . . . [Full Text of this Article]

The Ubiquity of the Birth-cohort Phenomenon

The Meaning of the Birth-cohort Phenomenon

A Strange Link with Inflammatory Bowel Disease

The Appearance of Helicobacter Pylori

Unresolved Issues

Conclusions

Acknowledgments

References


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