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IJE Advance Access published online on August 2, 2008
International Journal of Epidemiology, doi:10.1093/ije/dyn156
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Published by Oxford University Press on behalf of the International Epidemiological Association © The Author 2008; all rights reserved.
The online version of this article has been published under an open access model. Users are entitled to use, reproduce, disseminate, or display the open access version of this article for non-commercial purposes provided that: the original authorship is properly and fully attributed; the Journal and Oxford University Press are attributed as the original place of publication with the correct citation details given; if an article is subsequently reproduced or disseminated not in its entirety but only in part or as a derivative work this must be clearly indicated. For commercial re-use, please contact journals.permissions@oxfordjournals.org

Maternal protein-energy supplementation does not affect adolescent blood pressure in The Gambia

Sophie Hawkesworth1,*, Andrew M Prentice1,2, Anthony JC Fulford1,2 and Sophie E Moore2

1MRC International Nutrition Group, London School of Hygiene and Tropical Medicine, London, UK.
2MRC Keneba, MRC Laboratories, Fajara, The Gambia.

*Corresponding author: MRC International Nutrition Group, Nutrition and Public Health Intervention Research Unit, Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK. E-mail: sophie.hawkesworth{at}lshtm.ac.uk


  Abstract

Background Birthweight, and by inference maternal nutrition during pregnancy, is thought to be an important determinant of offspring blood pressure but the evidence base for this in humans is lacking data from randomized controlled trials.

Methods The offspring from a maternal prenatal protein-energy supplementation trial were enrolled into a follow-up study of chronic disease risk factors including blood pressure. Subjects were 11–17 years of age and blood pressure was measured in triplicate using an automated monitor (Omron 705IT). One-thousand two-hundred sixty seven individuals (71% of potential participants) were included in the analysis.

Results There was no difference in blood pressure between those whose mothers had consumed protein-energy biscuits during pregnancy and those whose mothers had consumed the same supplement post-partum. For systolic blood pressure the intention-to-treat regression coefficient was 0.46 (95% CI: –1.12, 2.04). Mean systolic blood pressure for control children was 110.2 (SD ± 9.3) mmHg and for intervention children was 110.8 (SD ± 8.8) mmHg. Mean diastolic blood pressure for control children was 64.7 (SD ± 7.7) mmHg and for intervention children was 64.6 (SD ± 7.6) mmHg.

Conclusions We have found no association between maternal prenatal protein-energy supplementation and offspring blood pressure in adolescence amongst rural Gambians. We found some evidence to suggest that offspring body composition may interact with the effect of maternal supplementation on blood pressure.

Keywords Blood pressure, maternal supplementation, The Gambia, DOHaD

Accepted 7 July 2008


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