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© 1980 Oxford University Press

research-article

Hypothesis Is Lactose a Dietary Risk Factor for Ischaemic Heart Disease?

JEFFREY J SEGALL*

*308 Cricklewood Lane, London, NW2, England

Segall JJ [308 Cricklewood Lane, London NW2, England]. Is Lactose a dietary risk factor for ischaemic heart disease? International Journal of Epidemiology 1980, 9: 271–276.

The prevalence of primary adult lactose malabsorption (LM) in 23 ethnic groups was matched with national data on milk consumption and mortality rates from ischaemic heart disease (IHD). In 6 other ethnic groups prevalence of LM was related to unquantified assessments of milk consumption and frequency of IHD.

On the available data, populations with a prevalence of LM over 30%, and whose consumption of milk is low or is largely in low lactose form, have a lower risk of IHD mortality than populations with a prevalence of LM under 30% and a high milk consumption. There is evidence against attributing these findings to genetic linkage between susceptibility to IHD mortality and persistent lactose absorption, or to differences in socio-economic development, cigarette consumption or intake of animal fats. The findings are compatible with an hypothesis that, if the correlation reported previously between milk consumption and IHD mortality is causal, lactose could be the responsible dietary factor.

Received 15 January 1980


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