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© 1979 Oxford University Press

research-article

Twelve Years Spirometric Changes Among Paris Area Workers

FRANCINE KAUFFMANN1, DOMINIQUE DROUET1, JOSEPH LELLOUCH2 and DENISE BRILLE1

1 Unité de Recherches de Physio-pathologie Respiratoire de l'INSERM (U.68), Hòpital Saint Antoine, F–75571 Paris, Cedex 12, France.
2 Unité de Recherches sur les Méthodes Statistiques et Epidémiologiques et leurs Applications a l'Etude des Maladies Chroniques INSERM (U.169).

Present address: INSERM U 169, 16 bis av. P.V. Couturier, F 94800 Villejuif, France.

Kauffman F (Unité de Recherches de Physio-pathologie Respiratoire de I'lNSERM (U. 68), Hopital Saint Antoine, F–75571 Paris, Cedex 12, France), Drouet D, Lellouch J and Brille D. Twelve years spirometric changes among Paris area workers. International Journal of Epidemiology 1979, 8: 201–212.

The effects of smoking habits, socio-occupational factors and respiratory symptoms in the development of airflow obstruction have been studied in a working population of 575 men aged 30–54 in 1960 and surveyed in 1960 and 1972. On average, FEV1, decreased by 47 ml/annum. Apart from FEV1 level, which reflects loss since the beginning of adult life, three factors were independently related to FEV1 slope: tobacco consumption, occupational exposure and social class. The decrease of FEV1 with smoking was dose related and decelerated among those who stopped smoking. This follow-up study ruled against phlegm as a causal factor of early stage airflow obstruction, although its role is not excluded at later stages.

Received 15 November 1978


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