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© 1978 Oxford University Press
research-article |
Studies of the Familial Aggregation of Chronic Bronchitis and Obstructive Airways Disease*
1Assistant Professor in MedicineHarvard Medical School
2Associate Professor of Preventive MedicineHarvard Medical School
3Associate Professor in MedicineHarvard School and Chief, Division of Clinical Epidemiology, Channing Laboratory
4Associate Professor of Microbiology and Molecular GeneticsHarvard Medical School
1 2 3 4 From the Divisions of Infectious Disease and Clinical Epidemiology, the Channing Laboratory, Harvard Medical School and the Peter Bent Brigham Division of the Affiliated Hospitals Inc. 180 Longwood Avenue, Boston Massachusetts 02115, USA
The familial aggregation of chronic branehitis and obstructive airways disease was investigated in a propositus population of 430 persons aged 45–54 years and 1340 of their first (1°), second (2°) and third (3°) order relatives. All subjects were screened in their homes using a modified British MRC respiratory disease questionnaire and a portable spirometer. 1° relatives of propositi with either chronic bronchitis or obstructive airways disease demonstrated up to a two-fold excess prevalence of chronic bronchitis when compared to 1° relatives of non-effected propositi. This excess prevalence of chronic bronchitis was independent of sex, cigarette smoking patterns, respiratory illness history, residence in a common household, geographical distribution within the study community and the presence of 
1-antitrypsin Pi variants. The prevalence of chronic bronchitis in 1° relatives of diseased propositi was also greater than in 2° relatives of diseased propositi, In whom the prevalence approximated that of the general population.
Received 25 November 1977
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