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© 1975 Oxford University Press

research-article

Seasonal Variations in the Clinical Presentation of Crohn's Disease and Ulcerative Colitis

D. R. CAVE1, and L. S. FREEDMAN2

1 Research Fellow of British Digestive Foundation, St. George's Hospital Medical School Hyde Park Corner, London, S.W.1, England
2 MRC Statistical Research and Services Unit, University College Hospital Medical School 115 Gower Street, London, WC1E 6AS, England

Reprint requests should be addressed to Dr. D. Cave

Epidemiological evidence that Crohn's disease could be a transmissible condition is limited. The case histories of 211 patients with Crohn's disease and 201 patients with ulcerative colitis have been scrutinized to ascertain whether there is a seasonal variation in the onset of symptomatic disease. Crohn's disease has a peak onset in January and July whereas ulceretive colitis has a possible peak of onset in December. A hypothesis is proposed that these findings provide epidemiological evidence, suggesting that Crohn's disease could be a transmissible condition, and that Crohn's disease and ulcerative colitis may not be aetiologically related.

Received 3 September 1975


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