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© 1975 Oxford University Press

research-article

Some Factors Related to Coronary Heart Disease Incidence in Honolulu Japanese Men: The Honolulu Heart Study

ABRAHAM KAGAN1,, TAVIA GORDON2, GEORGE G. RHOADS3 and JOYCE C. SCHIFFMAN4

1 2 3 4 Honolulu Heart Study and the Biometrics Research Branch, (U.S.) National Heart and Lung Institute Honolulu, Hawaii, and Bethesda, Maryland, U.S.A.

Reprint requests should be addressed to Dr. A. Kagan, Honolulu Heart Study, 347 North Kuakini Street, Honolulu, Hawaii 96817, U.S.A.

Eight thousand and six Japanese men born in the years 1900–1919 participated in the baseline examination of the Honolulu Heart Study. Of the survivors, 94.6 per cent participated in a second examination two years later. All but 23 of the second exam refusers were contacted about their health. These procedures identified 101 men who had developed coronary heart disease (CHD) for the first time during this two-year interval. This incidence was associated with elevated levels of serum cholesterol, blood pressure, relative weight, uric acid, and cigarette smoking. Considered by itself, non-fasting serum triglyceride was related to CHD incidence, but in the context of other (non-lipid) characteristics this apparent association was not significant. Cigarette smoking was related to CHD other than angina pectoris (AP) but not to AP alone, while the reverse was true for glucose intolerance. In this cohort, the association between relative weight and CHD was as strong as that between serum cholesterol and CHD.

Received 26 August 1975


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