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International Journal of Epidemiology 2008 37(Supplement 1):i46-i50; doi:10.1093/ije/dyn031
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Published by Oxford University Press on behalf of the International Epidemiological Association © The Author 2008; all rights reserved.

Design and implementation of a high-throughput biological sample processing facility using modern manufacturing principles

Paul Downey* and Tim C Peakman

UK Biobank, Unit 1 Spectrum Way, Cheadle, Stockport, Cheshire SK3 0SA, UK.

* Corresponding author. UK Biobank, Unit 1 Spectrum Way, Cheadle, Stockport, Cheshire SK3 0SA, UK. E-mail: paul.downey{at}ukbiobank.ac.uk


  Abstract

Background UK Biobank is a prospective study that is collecting biological samples and health and lifestyle data from 500 000 volunteer participants over a 4-year period. These data will be used to facilitate biological and medical research.

Methods Modern manufacturing principles were used to direct the development of the sample processing facility and automated systems.

Results A fit for purpose facility comprising technology, systems, dedicated process, infrastructure and an appropriate staff structure has been implemented that will deliver and maintain a resource that will support the long-term goals of the UK Biobank study.

Conclusions Modern manufacturing principles are appropriate for use in the development of a high throughput biological sample processing facility.

Keywords Design and implementation of a biobank, high throughput biological sample processing and archiving

Accepted 10 December 2007


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